You are running your hands over your 9-year-old Labrador’s coat during grooming and find a soft, movable lump under the skin along her ribcage, about the size of a grape. It was not there three months ago. She does not react when you press on it. Your next thought is a familiar, unsettling question: is this cancer? The honest answer is that you cannot know without a cellular examination. What you can do in the next 48 hours is have a veterinarian perform a fine needle aspirate, a procedure that takes about 60 seconds and provides enough information to determine whether this lump needs to come out now, come out eventually, or simply be monitored. Getting that answer is almost always better than six months of anxious guessing. A lump or mass on a dog is any abnormal accumulation of cells or fluid within or under the skin. Lumps arise from the uncontrolled or abnormal proliferation of cells from any tissue: fat cells (lipocytes) form lipomas, mast cells form mast cell tumors, hair follicle cells form follicular cysts, histiocytes form histiocytomas, and so on. The clinical behavior (benign vs. malignant) depends on the cell type, the degree of cellular differentiation, and the presence or absence of features that allow invasion into surrounding tissue or spread through lymphatic or blood vessels (metastasis). Benign tumors grow by expansion, are usually well-defined, and do not invade or metastasize. Malignant tumors grow by infiltration into surrounding tissue, may have irregular borders, and have the capacity to spread to lymph nodes, lungs, liver, or other organs. Physical examination cannot reliably distinguish benign from malignant; cytology and histopathology are required. Lipomas are benign tumors of mature adipocytes (fat cells) arising from the subcutaneous fat layer. They are the most frequently diagnosed skin mass in dogs, particularly common in middle-aged to senior overweight dogs and in breeds including Labrador Retrievers, Doberman Pinschers, and mixed breeds. They feel soft, rubbery, and movable under the skin, are usually non-painful, and grow slowly over months to years. Most are located along the trunk, shoulders, and upper limbs. Infiltrative lipomas are a subtype that infiltrate between muscle fascicles rather than displacing surrounding tissue; they feel less well-defined and firmer, and are more difficult to remove completely. A liposarcoma is the malignant counterpart, rare but indistinguishable from a lipoma by physical exam alone. FNA showing only lipocytes (fat cells) is consistent with a benign lipoma; histopathology after excision provides a definitive diagnosis. Treatment is removal only if the lipoma interferes with movement, causes discomfort, or grows rapidly. These are among the most common benign dermal masses in dogs. They arise from obstruction of a hair follicle or sebaceous gland, causing accumulation of keratinaceous material (keratin, sebum, and cellular debris) within a walled sac. They appear as smooth, round, firm-to-fluctuant nodules that may have a visible central pore. When they rupture, they discharge white, gray, or yellowish waxy material with a characteristic cheesy or rancid odor. They are benign and do not require removal unless they become chronically infected or rupture repeatedly causing skin inflammation. Squeezing them at home introduces skin flora and can cause a sterile cyst to become an infected abscess requiring drainage and systemic antibiotics. Histiocytomas are benign proliferations of epidermal Langerhans cells (dendritic immune cells) that appear as rapidly growing, solitary, pink-red, dome-shaped or ulcerated button-like masses, most commonly on the head, ear pinnae, and distal limbs. They are almost exclusively a disease of young dogs under 3 years of age, though occasionally seen in older dogs. The key clinical feature is spontaneous regression over 1-3 months without treatment as cytotoxic T-lymphocytes infiltrate and destroy the tumor cells. Despite their self-limiting nature, FNA is recommended before assuming regression because mast cell tumors, melanomas, and other malignancies can appear similar on external examination. In Shar-Pei dogs, disseminated histiocytic sarcoma (a different, malignant histiocytic neoplasm) must be distinguished from histiocytoma. Canine oral papillomatosis is caused by Canine Papillomavirus (CPV), particularly CPV-1, and produces multiple cauliflower-like warts on the lips, oral mucosa, gingiva, tongue, and occasionally the skin. It primarily affects young immunologically naive dogs and resolves spontaneously in 1-5 months as the immune system clears the virus. The warts are usually asymptomatic but can cause difficulty eating if large or numerous. Cutaneous papillomas in older dogs may be caused by different CPV types and may not regress; surgical removal or cryotherapy is curative for persistent lesions. Mast cell tumors (mastocytomas) arise from tissue mast cells and represent approximately 16-21% of all canine cutaneous tumors. They are the most common malignant skin tumor in dogs. MCTs are notorious for their variable and deceptive appearance: they can be flat, raised, ulcerated, pedunculated, pink, brown, or skin-colored; they can appear in hours, fluctuate in size (due to spontaneous degranulation of mast cell mediators), or remain unchanged for months. “Darier’s sign” (redness and wheal formation when the mass is palpated or scratched) is characteristic but not always present. They occur anywhere on the body but most commonly on the trunk, perineal region, and limbs. Boxers and Bulldogs have a high breed incidence but tend to develop lower-grade (less aggressive) tumors; Golden Retrievers, Labrador Retrievers, and Shar-Peis develop higher-grade tumors with worse prognoses. FNA cytology is highly diagnostic (mast cells contain characteristic metachromatic purple cytoplasmic granules). Histopathological grading (Patnaik grade I-III, or the two-tier Kiupel system: low vs. high grade) determines treatment and prognosis. Surgery with wide margins (2-3 cm lateral, one fascial plane deep) is the standard treatment for resectable MCTs; toceranib phosphate (Palladia) or masitinib are targeted molecular therapies for unresectable or metastatic disease. Antihistamines (diphenhydramine) and proton pump inhibitors (omeprazole) are given perioperatively to reduce systemic effects of mast cell degranulation during handling and surgery. Soft tissue sarcomas are a heterogeneous group of malignant tumors arising from mesenchymal tissues: fibrosarcoma, peripheral nerve sheath tumor (PNST), myxosarcoma, liposarcoma, leiomyosarcoma, and rhabdomyosarcoma are all included under this clinical grouping. They are locally aggressive with a low-to-moderate rate of metastasis. On examination, they are firm, often poorly circumscribed, and may adhere to underlying muscle or fascia. FNA is often non-diagnostic because these tumors have low cellularity (cells do not exfoliate well); incisional or excisional biopsy with histopathology is required for diagnosis. Treatment is wide surgical excision (2-3 cm margins are required to reduce local recurrence risk to below 20%); radiation therapy is used for incompletely excised tumors or as adjuvant treatment. Canine melanoma arises from melanocytes and presents differently depending on location. Cutaneous melanoma on haired skin is usually benign (melanocytoma); melanoma of the digit (toe), oral cavity, or mucocutaneous junction (lips, eyelids) is typically malignant with a high metastatic rate. Oral melanoma is the most common malignant oral tumor in dogs, accounting for approximately 30-40% of oral tumors. Digital melanoma presents as a swollen, painful toe that may resemble an infection or fractured nail before biopsy reveals the underlying tumor. The canine melanoma vaccine (Oncept, licensed conditionally in the US) is an immunotherapy approved for stage II-III oral melanoma after surgery; studies suggest improved survival times compared to surgery alone. SCC arises from the keratinocytes of the epidermis and is associated with chronic UV light exposure in lightly pigmented skin. Predilection sites in dogs are the nasal planum, lips, ear tips (in white cats more than dogs), digits, and ventral abdomen in thinly coated white dogs. Digital SCC in large breed dogs (Labrador Retrievers, Standard Poodles, Giant Schnauzers) often presents as a swollen, ulcerated, or missing toenail with underlying bone destruction, mimicking chronic nail bed infection. Radiographs showing bone lysis of the third phalanx in a dog with nail/digit swelling should prompt biopsy. Treatment is surgical amputation of the affected digit (often curative for single-digit disease), with radiation therapy for advanced or non-resectable lesions. If a lump is soft and moves around easily under the skin, it’s definitely just a fatty tumor and doesn’t need to be checked. Soft, movable lumps are most commonly lipomas, but a liposarcoma (the malignant equivalent) can be indistinguishable by physical examination alone, as can an early-stage mast cell tumor, a lymph node swelling, or a cyst. No lump can be definitively diagnosed as benign by its feel or movability alone. A fine needle aspirate takes less than two minutes, requires no anesthesia in most dogs, and provides enough information in the majority of cases to confirm a lipoma diagnosis or flag a more concerning cell type. The cost of not knowing is potentially a malignant tumor that grows unchecked for months while the owner assumes it is benign. Mast cell tumors always look like an obvious skin cancer: large, ugly, and ulcerated. Mast cell tumors are known among veterinary oncologists as “the great imposters” precisely because they can appear as any type of skin lesion. They have been mistaken for lipomas, insect bites, inflammatory lesions, follicular cysts, and warts before FNA revealed mast cells. A mast cell tumor may be flat, raised, fluctuating in size, pink, brown, or skin-colored. The only reliable way to identify an MCT is cytology or histopathology. Any new skin lump that changes size, becomes red after handling, or is in a breed with known MCT predisposition should be aspirated at the first examination. Squeezing or popping a sebaceous cyst will help it heal faster. Squeezing a sebaceous cyst forces its keratin contents into the surrounding dermis, triggering a foreign body inflammatory reaction (cyst rupture dermatitis) that is significantly more painful, inflamed, and difficult to treat than the original cyst. It also introduces skin bacteria into the cyst cavity, converting a sterile lesion into an infected abscess that may require surgical drainage and systemic antibiotics. A cyst that has never ruptured can often be left alone indefinitely or surgically excised cleanly as an elective procedure. Rupturing it manually creates a wound requiring medical management. Physical examination alone cannot determine whether a lump is cancerous. Features that increase concern include rapid growth (doubling in less than 4 weeks), ulceration or bleeding, a firm or poorly defined border that seems to grow into surrounding tissue, location in the mouth or on a digit, and accompanying signs like weight loss, enlarged lymph nodes, or lethargy. However, some malignant tumors (including early mast cell tumors) look entirely benign on examination. A fine needle aspirate (FNA) is the only reliable first-line method to assess the cell type of any lump, and it is inexpensive, quick, and requires no anesthesia in most dogs. Not necessarily. Confirmed benign masses (such as a lipoma confirmed by FNA) that are not causing discomfort, are not in a functional location, and are growing slowly may be monitored rather than removed. The decision to remove depends on location (a lipoma on the chest wall is less concerning than one compressing a nerve), size trajectory, and the dog’s overall health and anesthetic risk. Malignant masses should generally be removed promptly, with the goal of wide surgical margins. The most important principle is that the decision to monitor rather than remove should be made after a cellular diagnosis, not based on the assumption that the lump is benign. A lipoma is a benign growth of fat cells found under the skin; it is soft, movable, slow-growing, and non-painful. A mast cell tumor is the most common malignant skin tumor in dogs and requires surgical excision and often further treatment. The problem is that no one can reliably distinguish between them by physical examination alone: both can be soft, movable, and present anywhere on the body. A fine needle aspirate distinguishes them in most cases. Lipoma cytology shows fat vacuoles and lipocytes (fat cells). Mast cell tumor cytology shows characteristic mast cells with purple-staining cytoplasmic granules. This one-minute procedure is the most important step in assessing any skin lump in a dog. A stable lump that has been confirmed by FNA as benign and has shown no growth or change over years is generally low concern. However, if the lump has never been evaluated by FNA or biopsy, the stability does not confirm that it is benign. Some tumors grow very slowly for years before changing behavior. Any lump that has been present for more than 3 months without evaluation deserves an FNA. Additionally, if a lump that was previously stable begins to grow, change texture, or become associated with any other signs, it should be re-evaluated even if it was previously assessed as benign. No home remedy has any proven ability to treat, shrink, or resolve any type of skin tumor in dogs, including mast cell tumors, lipomas, or sebaceous cysts. Apple cider vinegar applied topically can cause chemical burns to the skin. Turmeric has anti-inflammatory properties but no demonstrated anti-tumor effect in dogs at oral doses that are safe to administer. The primary risk of using home remedies is the time lost while a potentially malignant tumor continues to grow unchecked and potentially spreads to lymph nodes or other organs, reducing the chances of a successful outcome from definitive treatment. The veterinarian will first perform a physical examination, assessing the lump’s size, location, consistency (soft vs. firm), borders (well-defined vs. infiltrating), mobility (freely movable vs. adherent to underlying tissue), and surface (smooth vs. ulcerated). If the lump is accessible, a fine needle aspirate will typically be performed: a small-gauge needle is inserted into the mass several times, the plunger drawn back to collect cells, and the aspirate placed on a slide and stained. The veterinarian may read the slide in-house or send it to an external pathologist. Based on the cytology result, the next step will be either surgical removal, further staging diagnostics (radiographs, ultrasound), a monitoring plan, or referral to an oncologist. Some tumor types have known breed predispositions with a likely genetic component. Mast cell tumors occur at significantly higher rates in Boxers, Bulldogs, and Shar-Peis. Hemangiosarcoma has a strong breed predisposition in Golden Retrievers and German Shepherds. Subungual squamous cell carcinoma is disproportionately common in Standard Poodles, Giant Schnauzers, and Gordon Setters, particularly those with black coats. These predispositions mean that owners of affected breeds should maintain a higher vigilance for new skin masses and discuss breed-appropriate screening intervals with their veterinarian. For more guides on keeping your dog healthy, browse all our Dog Health articles.
Dog Lumps: Types, Causes, When to Worry, and Treatment
Oncology and Internal Medicine
This article is reviewed for clinical accuracy. Always consult your veterinarian for diagnosis and treatment.
Key Takeaways
How Lumps Form: Basic Tumor Biology
Common Types of Dog Lumps: A Comparison
Lump Type
Typical Appearance
Malignant?
FNA Result
Lipoma
Soft, movable, subcutaneous; grows slowly; usually not attached to underlying tissue
No (liposarcoma is rare)
Lipocytes (fat cells); diagnosis usually confirmed by FNA
Mast cell tumor
Highly variable: flat, raised, ulcerated, or pedunculated; may fluctuate in size (“Darier’s sign”)
Yes (most common malignant skin tumor)
Mast cells with characteristic purple granules; FNA is highly diagnostic
Histiocytoma
Firm, dome-shaped, red, button-like; rapid growth; usually solitary; face, ears, limbs
No (benign, self-regressing)
Round cells with kidney-shaped nucleus; regresses in 1-3 months
Sebaceous cyst (epidermal inclusion cyst)
Smooth, round, firm-fluctuant; may have a dark central pore; discharges white cheesy material
No
Keratinaceous debris, cholesterol crystals, anucleate squames
Abscess
Warm, painful, fluctuant swelling; may have a draining tract; often with surrounding redness
No (infectious, not neoplastic)
Degenerate neutrophils, bacteria; culture for antibiotic selection
Soft tissue sarcoma
Firm, poorly defined; often in subcutaneous or muscular tissue; may adhere to underlying structures
Yes
FNA often non-diagnostic (low cellularity); excisional biopsy with wide margins required
Perianal adenoma
Pink-gray nodule around the anus; multiple or single; primarily intact male dogs
Adenoma: no. Adenocarcinoma: yes
Hepatoid cells; adenoma vs. adenocarcinoma requires histopathology
Cutaneous lymphoma
Thickened, erythematous, scaling skin plaques; diffuse or multifocal; resembles chronic dermatitis
Yes
Lymphocytes; immunophenotyping required to confirm
Benign Lumps: The Most Common Types
Lipoma
Sebaceous Cysts and Epidermal Inclusion Cysts
Histiocytoma
Warts (Viral Papillomas)
Malignant Lumps: The Most Important Types
Mast Cell Tumor (MCT)
Soft Tissue Sarcoma (STS)
Melanoma
Squamous Cell Carcinoma (SCC)
Red Flags: Veterinary Evaluation Within 1-2 Days
How Veterinarians Evaluate a Dog Lump
Diagnostic Test
What It Provides
When Used
Fine needle aspirate (FNA) cytology
Cell type identification; preliminary benign vs. malignant assessment; guides urgency of surgery
First-line evaluation of any new skin mass; quick, inexpensive, minimally invasive; diagnostic in 70-85% of cases
Histopathology (biopsy)
Definitive diagnosis; tumor grade; surgical margin assessment; mitotic index
After excisional surgery; incisional biopsy for large or deep masses before definitive surgery; any FNA non-diagnostic result
Lymph node aspirate
Metastatic spread to regional lymph nodes; staging information
Any confirmed malignant skin tumor; palpably enlarged lymph nodes near the mass
Thoracic radiographs (3 views)
Pulmonary metastasis; mediastinal lymphadenopathy
Staging for confirmed high-grade or malignant tumors before surgery; essential for STS, MCT grade II-III, melanoma, SCC
Abdominal ultrasound
Visceral metastasis; abdominal lymphadenopathy; splenic or hepatic involvement (especially for MCT, lymphoma)
Confirmed malignant tumors with known abdominal metastatic routes; MCT (splenic mast cell disease)
CT scan
Three-dimensional tumor extent; surgical planning; lymph node mapping; bone involvement
Facial, oral, or nasal tumors; soft tissue sarcomas in complex anatomical locations; pre-surgical planning
c-KIT mutation analysis (PCR)
KIT gene mutation status in mast cell tumors; predicts response to toceranib phosphate (Palladia)
Grade II-III mast cell tumors being considered for targeted molecular therapy
CBC, serum chemistry, urinalysis
Paraneoplastic effects; organ function before surgery or chemotherapy; baseline blood values
Any confirmed malignancy; pre-anesthetic workup for surgery
Treatment Options for Dog Lumps
Treatment
Best For
Notes
Surgical excision with wide margins (2-3 cm lateral, one fascial plane deep)
Mast cell tumors; soft tissue sarcomas; squamous cell carcinoma; any resectable malignant mass
Margin width is determined by tumor type; inadequate margins require re-excision; histopathology of excised specimen is required to confirm clean margins
Conservative excision (narrow margins)
Confirmed benign masses (lipomas, histiocytomas, cysts) where location or size limits wide excision
Acceptable for benign tumors; not appropriate for malignant tumors without confirmed low-grade histopathology
Fine needle aspirate and monitoring
Confirmed benign masses (grade I lipoma, cyst) not causing discomfort or functional impairment
Recheck every 1-3 months; rebiopsy if size increases more than 20% or character changes
Toceranib phosphate (Palladia) 2.75 mg/kg every other day
Recurrent or metastatic mast cell tumors with c-KIT mutations; inoperable MCT
Targeted tyrosine kinase inhibitor; response rate approximately 40% for MCT; GI side effects common; requires CBC monitoring every 2-4 weeks
Masitinib (Masivet/Kinavet) 12.5 mg/kg daily
Recurrent grade II-III mast cell tumors; c-KIT mutation positive cases
Alternative tyrosine kinase inhibitor; similar efficacy to toceranib; CBC and urinalysis monitoring required
Radiation therapy
Incompletely excised soft tissue sarcomas; nasal or oral tumors; adjuvant treatment for high-grade MCT
Requires referral to a radiation oncology center; typically 10-20 fractions over 2-4 weeks; significantly reduces local recurrence in STS
Chemotherapy (CCNU/lomustine, vinblastine, DTIC)
High-grade mast cell tumors; lymphoma; disseminated or metastatic disease
CCNU (lomustine) 70-90 mg/m2 every 3 weeks is first-line for high-grade MCT; CBC before each dose due to myelosuppression; hepatotoxicity monitoring required
Metronomic chemotherapy (low-dose cyclophosphamide plus NSAID)
Adjuvant treatment after incomplete excision of STS; anti-angiogenic mechanism
Oral, lower side effect profile than conventional chemotherapy; ongoing treatment for months to years; monitor CBC monthly
Canine melanoma vaccine (Oncept)
Stage II-III oral melanoma after surgical resection
DNA vaccine targeting human tyrosinase; conditionally licensed by USDA; administered by oncologist; 4 injections 2 weeks apart, then boosters every 6 months
Cryotherapy or laser ablation
Superficial benign masses (papillomas, small sebaceous cysts, eyelid tumors)
Office-based procedures; suitable for small, superficial, confirmed-benign lesions; not appropriate for malignant tumors
Age-Specific Considerations for Dog Lumps
Puppies (Under 12 Months)
Adult Dogs (1-7 Years)
Senior Dogs (8+ Years)
Breed-Specific Lump Risks
Breed
Primary Lump Risk
Key Notes
Boxer
Mast cell tumors (very high incidence); brain tumors; cutaneous lymphoma
Boxers frequently develop grade I-II MCTs that behave less aggressively than in other breeds; still require excision and histopathological grading
Golden Retriever
Hemangiosarcoma (spleen, heart); mast cell tumors; lipomas
Splenic hemangiosarcoma is a leading cause of sudden death in older Golden Retrievers; annual abdominal ultrasound recommended in dogs over 8 years
Labrador Retriever
Lipomas (highest incidence of any breed); mast cell tumors; soft tissue sarcoma
Not every lump in a Labrador is a lipoma; each new mass still requires FNA regardless of prior lipoma diagnosis history
Shar-Pei
Mast cell tumors; histiocytic sarcoma; cutaneous mucinosis
Shar-Peis develop aggressive, high-grade MCTs more often than Boxers; any MCT in a Shar-Pei should be treated as high-grade until proven otherwise
Doberman Pinscher
Lipomas (infiltrative type common); soft tissue sarcoma; oral melanoma
Infiltrative lipomas in Dobermans grow between muscle groups and are difficult to excise completely; MRI or CT is recommended for surgical planning
Standard Poodle, Giant Schnauzer
Squamous cell carcinoma of the digit (subungual SCC)
Black-coated large breeds have highest incidence; swollen, painful, or missing toenail with lytic bone changes on X-ray is SCC until proven otherwise
Cost to Evaluate and Treat Dog Lumps in the US
Service / Treatment
Typical US Cost
Veterinary exam
$60-$150
Fine needle aspirate with in-house cytology
$50-$150
FNA sent to external pathology lab
$100-$250
Surgical excision (small, superficial mass)
$300-$800
Surgical excision (large or deep mass, general anesthesia)
$800-$2,500
Histopathology of excised specimen
$150-$400
Thoracic radiographs (staging)
$150-$400
Abdominal ultrasound (staging)
$200-$500
CT scan
$800-$2,000
Radiation therapy (full course)
$5,000-$12,000
Toceranib phosphate (Palladia), monthly
$200-$500
Chemotherapy (CCNU per dose)
$100-$300
Myths and Facts About Dog Lumps
Frequently Asked Questions About Dog Lumps
How do I know if a lump on my dog is cancerous?
Should I have every lump on my dog removed?
What is the difference between a lipoma and a mast cell tumor?
My dog has a lump that has been there for years and never changed. Does it still need to be checked?
Can I use apple cider vinegar or turmeric to treat a dog lump at home?
What happens at the vet when my dog has a lump evaluated?
Are lumps in dogs hereditary?
Reviewed by a Licensed Veterinary Doctor (DVM)
Myth
Fact
Myth
Fact
Myth
Fact
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